Assay Detail
Functional
CHEMBL688820
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Inhibition of normal HFF (Human foreskin fibroblast) cell proliferation
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.92 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160303 | — | — | 1 | 4.92 |
| CHEMBL160846 | — | — | 1 | - |
| CHEMBL422347 | — | — | 1 | - |
| CHEMBL269620 | — | — | 1 | - |
| CHEMBL155761 | — | — | 1 | - |
| CHEMBL157084 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160303 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL160846 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL422347 | — | IC50 | > | 18000.0 | nM | - |
| CHEMBL269620 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL155761 | — | IC50 | > | 23000.0 | nM | - |
| CHEMBL157084 | — | IC50 | > | 10000.0 | nM | - |