Assay Detail
Functional
CHEMBL688955
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Concentration required to inhibit HIV-1 replication in H9 lymphocyte cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H9 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Anti-AIDS agents part 41: synthesis and anti-HIV activity of 3',4'-di-o-(-)-camphanoyl-(+)-cis-khellactone (DCK) lactam analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.73 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6396 | — | — | 1 | 9.62 |
| CHEMBL269559 | — | — | 1 | 9.59 |
| CHEMBL268653 | — | — | 1 | 8.34 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6396 | — | EC50 | = | 0.24 | nM | 9.62 |
| CHEMBL269559 | — | EC50 | = | 0.256 | nM | 9.59 |
| CHEMBL268653 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 45.0 | nM | 7.35 |