Assay Detail
Functional
CHEMBL688957
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated for the anti-HIV activity against HIV-1 replication in H9 lymphocyte cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H9 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.89 | 9.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282915 | — | — | 1 | 9.18 |
| CHEMBL292426 | — | — | 1 | 9.06 |
| CHEMBL273330 | — | — | 1 | 8.64 |
| CHEMBL263957 | — | — | 1 | 8.00 |
| CHEMBL54355 | — | — | 1 | 7.70 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.35 |
| CHEMBL55887 | — | — | 1 | 6.75 |
| CHEMBL54100 | — | — | 1 | 6.40 |
| CHEMBL54519 | — | — | 1 | - |
| CHEMBL404519 | BEVIRIMAT | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282915 | — | EC50 | = | 0.66 | nM | 9.18 |
| CHEMBL292426 | — | EC50 | = | 0.87 | nM | 9.06 |
| CHEMBL273330 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL263957 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL54355 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL55887 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL54100 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL54519 | — | EC50 | < | 180.0 | nM | - |
| CHEMBL404519 | BEVIRIMAT | EC50 | < | 0.35 | nM | - |