Assay Detail
Functional
CHEMBL688958
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against HIV-1 replication in acutely infected H9 lymphocytes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H9 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Anti-AIDS agents. Part 47: Synthesis and anti-HIV activity of 3-substituted 3',4'-Di-O-(S)-camphanoyl-(3'R,4'R)-(+)-cis-khellactone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.15 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308801 | — | — | 1 | 9.92 |
| CHEMBL310254 | — | — | 1 | 9.73 |
| CHEMBL269559 | — | — | 1 | 9.59 |
| CHEMBL430615 | — | — | 1 | 8.99 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.35 |
| CHEMBL310494 | — | — | 1 | 7.07 |
| CHEMBL409338 | — | — | 1 | 6.41 |
| CHEMBL306336 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308801 | — | EC50 | = | 0.119 | nM | 9.92 |
| CHEMBL310254 | — | EC50 | = | 0.188 | nM | 9.73 |
| CHEMBL269559 | — | EC50 | = | 0.256 | nM | 9.59 |
| CHEMBL430615 | — | EC50 | = | 1.03 | nM | 8.99 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL310494 | — | EC50 | = | 85.4 | nM | 7.07 |
| CHEMBL409338 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL306336 | — | EC50 | = | 690.0 | nM | 6.16 |