Assay Detail
Functional
CHEMBL688962
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Inhibitory activity against multidrug resistant HIV-1 strain RT-MDR
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H9 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Stereochemistry of halopyridyl and thiazolyl thiourea compounds is a major determinant of their potency as nonnucleoside inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.02 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432526 | — | — | 1 | 8.30 |
| CHEMBL295585 | — | — | 1 | 8.30 |
| CHEMBL292339 | — | — | 1 | 8.00 |
| CHEMBL39999 | TROVIRDINE | 2.0 | 1 | 7.70 |
| CHEMBL302866 | — | — | 1 | 7.22 |
| CHEMBL294743 | — | — | 1 | 6.70 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 6.40 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.30 |
| CHEMBL417737 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432526 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL295585 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL292339 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL39999 | TROVIRDINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL302866 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL294743 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL417737 | — | IC50 | = | 5600.0 | nM | 5.25 |