Assay Detail
Functional
CHEMBL689055
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the ability to inhibit H+/K+ -ATPase formation in rabbit gastric glands.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Stomach |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antiulcer agents. 5. Inhibition of gastric H+/K(+)-ATPase by substituted imidazo[1,2-a]pyridines and related analogues and its implication in modeling the high affinity potassium ion binding site of the gastric proton pump enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.15 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296482 | — | — | 1 | 7.19 |
| CHEMBL47529 | — | — | 1 | 7.19 |
| CHEMBL293244 | — | — | 1 | 6.89 |
| CHEMBL64216 | — | — | 1 | 6.51 |
| CHEMBL43945 | — | — | 1 | 6.40 |
| CHEMBL296544 | — | — | 1 | 5.84 |
| CHEMBL137742 | — | — | 1 | 5.42 |
| CHEMBL46595 | — | — | 1 | 5.09 |
| CHEMBL137700 | — | — | 1 | 4.85 |
| CHEMBL136140 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296482 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL47529 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL293244 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL64216 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL43945 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL296544 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL137742 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL46595 | — | IC50 | = | 8080.0 | nM | 5.09 |
| CHEMBL137700 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL136140 | — | IC50 | = | 442000.0 | nM | - |