Assay Detail
Functional
CHEMBL689114
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Inhibition of HIV-1 replication in H9 cells infected with three different concentrations of HIV IIIB strain
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H9 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Keto/enol epoxy steroids: a new structural class of HIV-1 Tat inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.03 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137861 | — | — | 1 | 6.52 |
| CHEMBL91609 | — | — | 1 | 6.22 |
| CHEMBL92554 | — | — | 1 | 5.92 |
| CHEMBL3137862 | — | — | 1 | 5.85 |
| CHEMBL2373186 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137861 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL91609 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL92554 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3137862 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2373186 | — | IC50 | = | 2400.0 | nM | 5.62 |