Assay Detail
Binding
CHEMBL689316
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of HIV-1 protease.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and pharmacokinetics of potent carbamate HIV-1 protease inhibitors containing novel high affinity hydroxyethylamine isosteres
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.82 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95546 | — | — | 1 | 9.59 |
| CHEMBL99336 | — | — | 1 | 9.55 |
| CHEMBL321949 | — | — | 1 | 9.40 |
| CHEMBL97585 | — | — | 1 | 9.38 |
| CHEMBL99214 | — | — | 1 | 9.12 |
| CHEMBL316717 | — | — | 1 | 9.02 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.00 |
| CHEMBL316718 | — | — | 1 | 8.89 |
| CHEMBL318129 | — | — | 1 | 8.85 |
| CHEMBL100048 | — | — | 1 | 8.77 |
| CHEMBL316608 | — | — | 1 | 8.70 |
| CHEMBL100271 | — | — | 1 | 8.59 |
| CHEMBL321778 | — | — | 1 | 8.59 |
| CHEMBL318894 | — | — | 1 | 8.52 |
| CHEMBL18067 | — | — | 1 | 8.37 |
| CHEMBL320602 | — | — | 1 | 8.28 |
| CHEMBL261340 | — | — | 1 | 8.09 |
| CHEMBL277801 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95546 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL99336 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL321949 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL97585 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL99214 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL316717 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL316718 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL318129 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL100048 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL316608 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL100271 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL321778 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL318894 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL18067 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL320602 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL261340 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL277801 | — | IC50 | = | 10.0 | nM | 8.00 |