Assay Detail
Functional
CHEMBL689332
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Compound was evaluated for in vitro inhibition of leukotriene (LTB4) in human peripheral blood polymorphonuclear leukocytes (HPMN)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Quinolines as potent 5-lipoxygenase inhibitors: synthesis and biological profile of L-746,530.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.26 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278293 | — | — | 1 | 8.80 |
| CHEMBL22789 | — | — | 1 | 8.64 |
| CHEMBL22751 | — | — | 1 | 8.40 |
| CHEMBL23007 | — | — | 1 | 8.24 |
| CHEMBL280348 | — | — | 1 | 8.22 |
| CHEMBL22578 | — | — | 1 | 8.00 |
| CHEMBL22736 | — | — | 1 | 7.99 |
| CHEMBL417464 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278293 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL22789 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL22751 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL23007 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL280348 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL22578 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL22736 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL417464 | — | IC50 | = | 18.0 | nM | 7.75 |