Assay Detail
Binding
CHEMBL689340
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
DNA helicase/primase complex protein (CHEMBL4380) ↗| Type | SINGLE PROTEIN |
| Organism | Herpes simplex virus (type 1 / strain 17) |
Publication
Inhibition of herpes simplex virus type 1 helicase-primase by (dichloroanilino)purines and -pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.07 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301283 | — | — | 1 | 6.11 |
| CHEMBL53605 | — | — | 1 | 6.07 |
| CHEMBL54127 | — | — | 1 | 6.07 |
| CHEMBL51613 | — | — | 1 | 6.06 |
| CHEMBL53307 | — | — | 1 | 6.04 |
| CHEMBL51501 | — | — | 1 | 6.04 |
| CHEMBL298714 | — | — | 1 | - |
| CHEMBL52034 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301283 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL53605 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL54127 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL51613 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL53307 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL51501 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL298714 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL52034 | — | IC50 | > | 2000.0 | nM | - |