Assay Detail
Functional
CHEMBL689452
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Inhibitory activity against HT-29 colon cancer cell line
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.08 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL151313 | — | — | 1 | 6.54 |
| CHEMBL151831 | — | — | 1 | 6.42 |
| CHEMBL151336 | — | — | 1 | 6.38 |
| CHEMBL356649 | — | — | 1 | 6.34 |
| CHEMBL346445 | — | — | 1 | 6.26 |
| CHEMBL345312 | — | — | 1 | 6.14 |
| CHEMBL150994 | — | — | 1 | 6.01 |
| CHEMBL356208 | — | — | 1 | 5.90 |
| CHEMBL348438 | — | — | 1 | 5.87 |
| CHEMBL415735 | — | — | 1 | 5.60 |
| CHEMBL149352 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL151313 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL151831 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL151336 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL356649 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL346445 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL345312 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL150994 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL356208 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL348438 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL415735 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL149352 | — | IC50 | = | 3630.0 | nM | 5.44 |