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Assay Detail

CHEMBL689551

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Functional
In vitro antiproliferative activity against human carcinoma cell line H460 (lung)
ChEMBL ↗
69
Total Activities
69
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type NCI-H460
Confidence 1 — Organism
Curated By Expert

Target

NCI-H460 (CHEMBL396) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles.
Engler TA, Furness K, Malhotra S, Sanchez-Martinez C, Shih C, Xie W, Zhu G, Zhou X, Conner S, Faul MM, Sullivan KA, Kolis SP, Brooks HB, Patel B, Schultz RM, DeHahn TB, Kirmani K, Spencer CD, Watkins SA, Considine EL, Dempsey JA, Ogg CA, Stamm NB, Anderson BD, Campbell RM, Vasudevan V, Lytle ML.
Bioorg Med Chem Lett (2003) 13 : 2261 -2267
PubMed 12824014 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 69 5.82 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL75368 — — 1 6.85
CHEMBL308979 — — 1 6.68
CHEMBL74637 — — 1 6.64
CHEMBL76326 — — 1 6.48
CHEMBL72076 — — 1 6.43
CHEMBL73343 — — 1 6.30
CHEMBL268368 STAUROSPORINE AGLYCON — 1 6.23
CHEMBL74883 — — 1 6.16
CHEMBL72069 — — 1 6.15
CHEMBL74289 — — 1 6.14
CHEMBL76464 — — 1 6.05
CHEMBL308541 — — 1 5.99
CHEMBL311851 — — 1 5.98
CHEMBL308099 — — 1 5.97
CHEMBL306748 — — 1 5.97
CHEMBL430606 — — 1 5.96
CHEMBL76337 — — 1 5.96
CHEMBL306611 — — 1 5.96
CHEMBL306856 — — 1 5.95
CHEMBL72754 — — 1 5.95
CHEMBL308116 — — 1 5.93
CHEMBL73485 — — 1 5.89
CHEMBL73781 — — 1 5.89
CHEMBL73718 — — 1 5.88
CHEMBL310260 — — 1 5.88
CHEMBL312292 — — 1 5.87
CHEMBL73751 — — 1 5.84
CHEMBL73794 — — 1 5.83
CHEMBL72077 — — 1 5.79
CHEMBL307152 — — 1 5.78

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL75368 — IC50 = 140.0 nM 6.85
CHEMBL308979 — IC50 = 210.0 nM 6.68
CHEMBL74637 — IC50 = 230.0 nM 6.64
CHEMBL76326 — IC50 = 330.0 nM 6.48
CHEMBL72076 — IC50 = 370.0 nM 6.43
CHEMBL73343 — IC50 = 500.0 nM 6.30
CHEMBL268368 STAUROSPORINE AGLYCON IC50 = 590.0 nM 6.23
CHEMBL74883 — IC50 = 690.0 nM 6.16
CHEMBL72069 — IC50 = 710.0 nM 6.15
CHEMBL74289 — IC50 = 720.0 nM 6.14
CHEMBL76464 — IC50 = 900.0 nM 6.05
CHEMBL308541 — IC50 = 1020.0 nM 5.99
CHEMBL311851 — IC50 = 1050.0 nM 5.98
CHEMBL306748 — IC50 = 1070.0 nM 5.97
CHEMBL308099 — IC50 = 1080.0 nM 5.97
CHEMBL430606 — IC50 = 1110.0 nM 5.96
CHEMBL306611 — IC50 = 1090.0 nM 5.96
CHEMBL76337 — IC50 = 1100.0 nM 5.96
CHEMBL306856 — IC50 = 1130.0 nM 5.95
CHEMBL72754 — IC50 = 1130.0 nM 5.95
CHEMBL308116 — IC50 = 1170.0 nM 5.93
CHEMBL73485 — IC50 = 1300.0 nM 5.89
CHEMBL73781 — IC50 = 1280.0 nM 5.89
CHEMBL73718 — IC50 = 1310.0 nM 5.88
CHEMBL310260 — IC50 = 1320.0 nM 5.88
CHEMBL312292 — IC50 = 1350.0 nM 5.87
CHEMBL73751 — IC50 = 1430.0 nM 5.84
CHEMBL73794 — IC50 = 1480.0 nM 5.83
CHEMBL72077 — IC50 = 1630.0 nM 5.79
CHEMBL307152 — IC50 = 1670.0 nM 5.78
CHEMBL73772 — IC50 = 1680.0 nM 5.78
CHEMBL73742 — IC50 = 1770.0 nM 5.75
CHEMBL306047 — IC50 = 1910.0 nM 5.72
CHEMBL308252 — IC50 = 1920.0 nM 5.72
CHEMBL306034 — IC50 = 2110.0 nM 5.68
CHEMBL307150 — IC50 = 2260.0 nM 5.65
CHEMBL73413 — IC50 = 2350.0 nM 5.63
CHEMBL76332 — IC50 = 2420.0 nM 5.62
CHEMBL75610 — IC50 = 2470.0 nM 5.61
CHEMBL306501 — IC50 = 2440.0 nM 5.61
CHEMBL72661 — IC50 = 2480.0 nM 5.61
CHEMBL307630 — IC50 = 2470.0 nM 5.61
CHEMBL307219 — IC50 = 2710.0 nM 5.57
CHEMBL73764 — IC50 = 2820.0 nM 5.55
CHEMBL72607 — IC50 = 2900.0 nM 5.54
CHEMBL441258 — IC50 = 3200.0 nM 5.50
CHEMBL306114 — IC50 = 3410.0 nM 5.47
CHEMBL75984 — IC50 = 3350.0 nM 5.47
CHEMBL310491 — IC50 = 3410.0 nM 5.47
CHEMBL76499 — IC50 = 3510.0 nM 5.46