Assay Detail
Functional
CHEMBL689638
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Equilibrium binding constant at the active site of HIV-1 reverse transcriptase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Effects of fluorine substitution of cytosine analogues on the binding affinity to HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 4.64 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL341421 | EMTRICITABINE 5'-TRIPHOSPHATE | -1.0 | 1 | 4.92 |
| CHEMBL1230 | LAMIVUDINE TRIPHOSPHATE | -1.0 | 1 | 4.82 |
| CHEMBL341799 | — | — | 1 | 4.75 |
| CHEMBL136440 | — | — | 1 | 4.51 |
| CHEMBL138054 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL341421 | EMTRICITABINE 5'-TRIPHOSPHATE | Kd | = | 12000.0 | nM | 4.92 |
| CHEMBL1230 | LAMIVUDINE TRIPHOSPHATE | Kd | = | 15000.0 | nM | 4.82 |
| CHEMBL341799 | — | Kd | = | 18000.0 | nM | 4.75 |
| CHEMBL136440 | — | Kd | = | 31000.0 | nM | 4.51 |
| CHEMBL138054 | — | Kd | = | 64000.0 | nM | 4.19 |