Assay Detail
Binding
CHEMBL689897
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cross Resistance (antiviral activity) with 4xAZT (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.48 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293961 | — | — | 1 | 7.00 |
| CHEMBL58581 | — | — | 1 | 6.57 |
| CHEMBL135127 | — | — | 1 | 6.52 |
| CHEMBL53554 | THIAZOLOBENZIMIDAZOLE | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293961 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL58581 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL135127 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL53554 | THIAZOLOBENZIMIDAZOLE | EC50 | = | 1500.0 | nM | 5.82 |