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Assay Detail

CHEMBL690082

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity was measured by plaque assay against HSV-1 virus by ELISA method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 1
Confidence 1 — Organism
Curated By Expert

Target

Human alphaherpesvirus 1 (CHEMBL377)
Type ORGANISM
Organism Human alphaherpesvirus 1

Publication

Design, synthesis, and antiviral evaluation of 2-chloro-5,6-dihalo-1-beta-D-ribofuranosylbenzimidazoles as potential agents for human cytomegalovirus infections.
Zou R, Drach JC, Townsend LB.
J Med Chem (1997) 40 : 811 -818
PubMed 9057868 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.47 5.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL182 GANCICLOVIR 4.0 1 5.46
CHEMBL165944 1 4.60
CHEMBL134238 1 4.29
CHEMBL607654 1 4.24
CHEMBL353310 1 4.19
CHEMBL165998 1 4.05
CHEMBL165942 1 -
CHEMBL608771 1 -
CHEMBL165943 1 -
CHEMBL609357 1 -
CHEMBL608488 1 -
CHEMBL513232 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL182 GANCICLOVIR IC50 = 3500.0 nM 5.46
CHEMBL165944 IC50 = 25000.0 nM 4.60
CHEMBL134238 IC50 = 51000.0 nM 4.29
CHEMBL607654 IC50 = 57000.0 nM 4.24
CHEMBL353310 IC50 = 65000.0 nM 4.19
CHEMBL165998 IC50 = 90000.0 nM 4.05
CHEMBL165942 IC50 > 100000.0 nM -
CHEMBL608771 IC50 > 100000.0 nM -
CHEMBL165943 IC50 > 100000.0 nM -
CHEMBL609357 IC50 > 100000.0 nM -
CHEMBL608488 IC50 > 100000.0 nM -
CHEMBL513232 IC50 = 102000.0 nM -