Assay Detail
Functional
CHEMBL690104
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Concentration required to inhibit 50% growth of human colon carcinoma cell line (HT-29)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, topoisomerase I inhibitory activity, and in vivo evaluation of 11-azacamptothecin analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.65 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13935 | — | — | 1 | 9.00 |
| CHEMBL273734 | — | — | 1 | 8.15 |
| CHEMBL13787 | — | — | 1 | 7.77 |
| CHEMBL13707 | — | — | 1 | 7.58 |
| CHEMBL276460 | — | — | 1 | 6.91 |
| CHEMBL268978 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13935 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL273734 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL13787 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL13707 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL276460 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL268978 | — | IC50 | = | 351.0 | nM | 6.46 |