Assay Detail
Functional
CHEMBL690105
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Concentration required to inhibit 50% growth of vinblastine resistant ovarian cancer cell line(SKVLB)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, topoisomerase I inhibitory activity, and in vivo evaluation of 11-azacamptothecin analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.67 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13746 | — | — | 1 | 7.82 |
| CHEMBL13523 | — | — | 1 | 6.59 |
| CHEMBL275134 | — | — | 1 | 6.28 |
| CHEMBL13349 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13746 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL13523 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL275134 | — | IC50 | = | 527.0 | nM | 6.28 |
| CHEMBL13349 | — | IC50 | = | 1030.0 | nM | 5.99 |