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Assay Detail

CHEMBL690119

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Ability to cause aggregation of purified HeLa cell DNA
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Expert

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and DNA-binding properties of polyamine analogues.
Edwards ML, Snyder RD, Stemerick DM.
J Med Chem (1991) 34 : 2414 -2420
PubMed 1875339 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 4.18 4.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL28489 1 4.46
CHEMBL80874 1 4.43
CHEMBL81614 1 4.40
CHEMBL28192 1 4.22
CHEMBL23194 SPERMINE 0.5 1 4.16
CHEMBL80796 1 4.07
CHEMBL78409 1 4.07
CHEMBL80313 1 4.02
CHEMBL80511 1 4.00
CHEMBL79044 1 4.00
CHEMBL81075 1 -
CHEMBL28743 NORSPERMIDINE 1 -
CHEMBL29818 1 -
CHEMBL79069 1 -
CHEMBL19612 SPERMIDINE 3.0 1 -
CHEMBL77442 1 -
CHEMBL82254 1 -
CHEMBL82255 1 -
CHEMBL80188 1 -
CHEMBL28866 1 -
CHEMBL81822 1 -
CHEMBL40258 1 -
CHEMBL420586 1 -
CHEMBL80850 1 -
CHEMBL46257 PUTRESCINE 3.0 1 -
CHEMBL78613 1 -
CHEMBL79172 1 -
CHEMBL79047 1 -
CHEMBL81145 1 -
CHEMBL78246 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL28489 IC50 = 35000.0 nM 4.46
CHEMBL80874 IC50 = 37000.0 nM 4.43
CHEMBL81614 IC50 = 40000.0 nM 4.40
CHEMBL28192 IC50 = 60000.0 nM 4.22
CHEMBL23194 SPERMINE IC50 = 70000.0 nM 4.16
CHEMBL80796 IC50 = 85000.0 nM 4.07
CHEMBL78409 IC50 = 85000.0 nM 4.07
CHEMBL80313 IC50 = 95000.0 nM 4.02
CHEMBL80511 IC50 = 100000.0 nM 4.00
CHEMBL79044 IC50 = 100000.0 nM 4.00
CHEMBL77442 IC50 = 3100000.0 nM -
CHEMBL284417 IC50 = 220000.0 nM -
CHEMBL82254 IC50 = 750000.0 nM -
CHEMBL82255 IC50 = 600000.0 nM -
CHEMBL80188 IC50 = 110000.0 nM -
CHEMBL28866 IC50 > 15000000.0 nM -
CHEMBL79630 IC50 = 7000000.0 nM -
CHEMBL81149 IC50 = 200000.0 nM -
CHEMBL312505 IC50 = 2500000.0 nM -
CHEMBL29142 IC50 = 300000.0 nM -
CHEMBL78198 IC50 = 170000.0 nM -
CHEMBL78670 IC50 = 200000.0 nM -
CHEMBL27912 IC50 = 340000.0 nM -
CHEMBL27909 IC50 = 150000.0 nM -
CHEMBL19612 SPERMIDINE IC50 = 1500000.0 nM -
CHEMBL79069 IC50 > 8000000.0 nM -
CHEMBL29818 IC50 = 180000.0 nM -
CHEMBL28743 NORSPERMIDINE IC50 = 3000000.0 nM -
CHEMBL81075 IC50 = 250000.0 nM -
CHEMBL81822 IC50 = 150000.0 nM -
CHEMBL40258 IC50 = 150000.0 nM -
CHEMBL420586 IC50 = 400000.0 nM -
CHEMBL80850 IC50 = 3000000.0 nM -
CHEMBL46257 PUTRESCINE IC50 = 12000000.0 nM -
CHEMBL78613 IC50 = 250000.0 nM -
CHEMBL79172 IC50 = 105000.0 nM -
CHEMBL79047 IC50 = 400000.0 nM -
CHEMBL81145 IC50 = 2400000.0 nM -
CHEMBL78246 IC50 = 200000.0 nM -