Assay Detail
Functional
CHEMBL690279
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for cytotoxicity in human foreskin fibroblasts at time of HCMV plaque enumeration
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, antiproliferative, and antiviral activity of 4-amino-1-(beta-D-ribofuranosyl)pyrrolo[2,3-d]pyridazin-7(6H)-one and related derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.60 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267099 | TUBERCIDIN | — | 1 | 6.40 |
| CHEMBL609505 | — | — | 1 | 6.00 |
| CHEMBL62099 | — | — | 1 | 5.92 |
| CHEMBL611857 | — | — | 1 | 5.68 |
| CHEMBL2093055 | — | — | 1 | 5.60 |
| CHEMBL611541 | — | — | 1 | 4.00 |
| CHEMBL2092780 | — | — | 1 | - |
| CHEMBL3144065 | — | — | 1 | - |
| CHEMBL603718 | — | — | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267099 | TUBERCIDIN | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL609505 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL62099 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL611857 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2093055 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL611541 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2092780 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3144065 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL603718 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | IC50 | > | 100000.0 | nM | - |