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Assay Detail

CHEMBL690283

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Visual cytotoxicity against stationary human foreskin fibroblasts (HFF) cells at the time of HCMV plaque enumeration
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type HFF
Confidence 1 — Organism
Curated By Expert

Target

HFF (CHEMBL614071)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis, and biological evaluation of tricyclic nucleosides (dimensional probes) as analogues of certain antiviral polyhalogenated benzimidazole ribonucleosides.
Zhu Z, Lippa B, Drach JC, Townsend LB.
J Med Chem (2000) 43 : 2430 -2437
PubMed 10882370 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.52 5.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL610950 1 5.50
CHEMBL610090 1 4.75
CHEMBL609495 1 4.70
CHEMBL609780 1 4.70
CHEMBL611846 1 4.68
CHEMBL375530 DICHLORORIBOBENZIMIDAZOLE 1 4.62
CHEMBL608898 1 4.50
CHEMBL610087 1 4.50
CHEMBL609497 1 4.50
CHEMBL610947 1 4.35
CHEMBL610660 1 4.00
CHEMBL2311203 1 4.00
CHEMBL610652 1 4.00
CHEMBL611855 1 -
CHEMBL513232 1 -
CHEMBL609781 1 -
CHEMBL182 GANCICLOVIR 4.0 1 -
CHEMBL2093916 1 -
CHEMBL609195 1 -
CHEMBL610364 1 -
CHEMBL609778 1 -
CHEMBL610368 1 -
CHEMBL611534 1 -
CHEMBL610944 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL610950 IC50 = 3200.0 nM 5.50
CHEMBL610090 IC50 = 18000.0 nM 4.75
CHEMBL609495 IC50 = 20000.0 nM 4.70
CHEMBL609780 IC50 = 20000.0 nM 4.70
CHEMBL611846 IC50 = 21000.0 nM 4.68
CHEMBL375530 DICHLORORIBOBENZIMIDAZOLE IC50 = 24000.0 nM 4.62
CHEMBL608898 IC50 = 32000.0 nM 4.50
CHEMBL610087 IC50 = 32000.0 nM 4.50
CHEMBL609497 IC50 = 32000.0 nM 4.50
CHEMBL610947 IC50 = 45000.0 nM 4.35
CHEMBL610660 IC50 = 100000.0 nM 4.00
CHEMBL2311203 IC50 = 100000.0 nM 4.00
CHEMBL610652 IC50 = 100000.0 nM 4.00
CHEMBL611855 IC50 > 10000.0 nM -
CHEMBL513232 IC50 = 238000.0 nM -
CHEMBL609781 IC50 > 100000.0 nM -
CHEMBL182 GANCICLOVIR IC50 > 100000.0 nM -
CHEMBL2093916 IC50 > 100000.0 nM -
CHEMBL609195 IC50 > 100000.0 nM -
CHEMBL610364 IC50 > 100000.0 nM -
CHEMBL609778 IC50 > 10000.0 nM -
CHEMBL610368 IC50 > 100000.0 nM -
CHEMBL611534 IC50 > 100000.0 nM -
CHEMBL610944 IC50 > 100000.0 nM -