Assay Detail
Functional
CHEMBL690446
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Compound was tested for [Ca2+] mobilization in NPY5 transfected human Bowes melanoma (HMCB) cell line.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HMCB |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationship studies on 2-heteroaryl-4-arylimidazoles NPY5 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.51 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326483 | — | — | 1 | 8.49 |
| CHEMBL120586 | — | — | 1 | 7.89 |
| CHEMBL120332 | — | — | 1 | 7.82 |
| CHEMBL332598 | — | — | 1 | 7.77 |
| CHEMBL339652 | — | — | 1 | 7.62 |
| CHEMBL332381 | — | — | 1 | 7.44 |
| CHEMBL120117 | — | — | 1 | 7.41 |
| CHEMBL119507 | — | — | 1 | 7.40 |
| CHEMBL422608 | — | — | 1 | 7.35 |
| CHEMBL332582 | — | — | 1 | 7.28 |
| CHEMBL122120 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326483 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL120586 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL120332 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL332598 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL339652 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL332381 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL120117 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL119507 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL422608 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL332582 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL122120 | — | EC50 | = | 723.0 | nM | 6.14 |