Assay Detail
Functional
CHEMBL690449
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Inhibitory concentration required to reduce normal human epithelial cell line (HMEC), growth by 50% in MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HMEC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.52 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 5.80 |
| CHEMBL95313 | — | — | 1 | 5.70 |
| CHEMBL95273 | — | — | 1 | 5.40 |
| CHEMBL99456 | — | — | 1 | 5.16 |
| CHEMBL99216 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL95313 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL95273 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL99456 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL99216 | — | IC50 | > | 20000.0 | nM | - |