Assay Detail
Functional
CHEMBL690458
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In vitro ability to inhibit the calcium mobilization induced by neurotensin (NT) in HT-29 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel small molecule neurotensin antagonists: 3-(1,5-diaryl-1,5-dioxopentan-3-yl)benzoic acids
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.70 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506981 | REMINERTANT | 3.0 | 1 | 6.80 |
| CHEMBL152825 | — | — | 1 | 5.66 |
| CHEMBL347989 | — | — | 1 | 5.34 |
| CHEMBL152626 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506981 | REMINERTANT | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL152825 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL347989 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL152626 | — | IC50 | = | 10000.0 | nM | 5.00 |