Assay Detail
Functional
CHEMBL690460
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Cytotoxic potency required to inhibit HT-29 cell growth by 50% after cell drug contact for 144 hrs
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
1-[(omega-aminoalkyl)amino]-4-[N-(omega-aminoalkyl)carbamoyl]-9-oxo-9, 10-dihydroacridines as intercalating cytotoxic agents: synthesis, DNA binding, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.16 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.00 |
| CHEMBL104900 | — | — | 1 | 7.03 |
| CHEMBL327096 | — | — | 1 | 6.72 |
| CHEMBL125371 | — | — | 1 | 6.35 |
| CHEMBL105362 | — | — | 1 | 6.30 |
| CHEMBL123024 | — | — | 1 | 6.24 |
| CHEMBL104004 | — | — | 1 | 5.70 |
| CHEMBL126010 | — | — | 1 | 5.52 |
| CHEMBL340343 | — | — | 1 | 5.35 |
| CHEMBL124605 | — | — | 1 | 5.35 |
| CHEMBL125180 | — | — | 1 | 5.24 |
| CHEMBL121823 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL104900 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL327096 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL125371 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL105362 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL123024 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL104004 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL126010 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL340343 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL124605 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL125180 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL121823 | — | IC50 | > | 23000.0 | nM | - |