Assay Detail
Functional
CHEMBL690468
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In vitro cytotoxic activity required to inhibit human colon adenocarcinoma HT-29 cell line
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
A new generation of N-aryl-N'-(1-alkyl-2-chloroethyl)ureas as microtubule disrupters: synthesis, antiproliferative activity, and beta-tubulin alkylation kinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.93 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148361 | — | — | 1 | 6.00 |
| CHEMBL423394 | — | — | 1 | 5.89 |
| CHEMBL358165 | — | — | 1 | 5.75 |
| CHEMBL145811 | — | — | 1 | 5.72 |
| CHEMBL356033 | — | — | 1 | 5.64 |
| CHEMBL150008 | — | — | 1 | 5.64 |
| CHEMBL148690 | — | — | 1 | 5.58 |
| CHEMBL149179 | — | — | 1 | 5.41 |
| CHEMBL146303 | — | — | 1 | 5.40 |
| CHEMBL357489 | — | — | 1 | 5.22 |
| CHEMBL435623 | — | — | 1 | 5.19 |
| CHEMBL423213 | — | — | 1 | 5.18 |
| CHEMBL149175 | — | — | 1 | 5.00 |
| CHEMBL146268 | — | — | 1 | 4.89 |
| CHEMBL146242 | — | — | 1 | 4.70 |
| CHEMBL344111 | — | — | 1 | 4.62 |
| CHEMBL148438 | — | — | 1 | 4.60 |
| CHEMBL146613 | — | — | 1 | 4.55 |
| CHEMBL358809 | — | — | 1 | 4.55 |
| CHEMBL149176 | — | — | 1 | 4.55 |
| CHEMBL356185 | — | — | 1 | 4.47 |
| CHEMBL148563 | — | — | 1 | 4.41 |
| CHEMBL149180 | — | — | 1 | 4.32 |
| CHEMBL434698 | — | — | 1 | 4.29 |
| CHEMBL149267 | — | — | 1 | 4.19 |
| CHEMBL150060 | — | — | 1 | 4.12 |
| CHEMBL146600 | — | — | 1 | 4.10 |
| CHEMBL149503 | — | — | 1 | 4.07 |
| CHEMBL146586 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148361 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL423394 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL358165 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL145811 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL356033 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL150008 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL148690 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL149179 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL146303 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL357489 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL435623 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL423213 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL149175 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL146268 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL146242 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL344111 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL148438 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL146613 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL358809 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL149176 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL356185 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL148563 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL149180 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL434698 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL149267 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL150060 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL146600 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL149503 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL146586 | — | IC50 | > | 100000.0 | nM | - |