Assay Detail
Functional
CHEMBL690469
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In vitro cytotoxicity against human tumor HT-29 cell line was measured as concentration to reduce [3H]thymidine uptake to 50% of that of the controls
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Unsymmetrical DNA cross-linking agents: combination of the CBI and PBD pharmacophores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.45 | 10.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302363 | — | — | 1 | 10.68 |
| CHEMBL307572 | — | — | 1 | 9.60 |
| CHEMBL279754 | DSB-120 | — | 1 | 8.06 |
| CHEMBL302536 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302363 | — | IC50 | = | 0.021 | nM | 10.68 |
| CHEMBL307572 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL279754 | DSB-120 | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL302536 | — | IC50 | = | 0.0027 | nM | - |