Assay Detail
Functional
CHEMBL690470
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Inhibition of cell growth against HT-29 human gastrointestinal adenocarcinoma cell lines in vitro
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of 5-chloro-5,8-dideaza analogues of folic acid and aminopterin targeted for colon adenocarcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.27 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37061 | — | — | 1 | 8.64 |
| CHEMBL36323 | — | — | 1 | 8.52 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.75 |
| CHEMBL39674 | — | — | 1 | 7.60 |
| CHEMBL36866 | — | — | 1 | 7.22 |
| CHEMBL35936 | — | — | 1 | 5.96 |
| CHEMBL39851 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37061 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL36323 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL39674 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL36866 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL35936 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL39851 | — | IC50 | = | 6700.0 | nM | 5.17 |