Assay Detail

CHEMBL690472

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Functional

Inhibition of HT-29 colon carcinoma cell proliferation

ChEMBL ↗

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Target

HT-29 (CHEMBL384) ↗

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Primary target HT-29

CHEMBL384

Anchored from Assay target.

Protein identity HT-29

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HT-29
Confidence	1 — Organism
Curated By	Expert

Target

HT-29 (CHEMBL384) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum.

Gompel M, Leost M, De Kier Joffe EB, Puricelli L, Franco LH, Palermo J, Meijer L.
Bioorg Med Chem Lett (2004) 14 : 1703 -1704
PubMed 15026054 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	4.85	5.26

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL44541	MERIDIANIN C	—	1	5.26
CHEMBL46440	MERIDIANIN D	—	1	4.44

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL44541	MERIDIANIN C	IC50	=	5500.0	nM	5.26
CHEMBL46440	MERIDIANIN D	IC50	=	36600.0	nM	4.44