Assay Detail
Functional
CHEMBL690475
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Inhibitory concentration that reduced the viability of HT 29 cell population by 50%.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.36 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.06 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.55 |
| CHEMBL72627 | — | — | 1 | 5.55 |
| CHEMBL72828 | — | — | 1 | 5.47 |
| CHEMBL311855 | — | — | 1 | 5.22 |
| CHEMBL64874 | — | — | 1 | 5.21 |
| CHEMBL73002 | — | — | 1 | 5.21 |
| CHEMBL312306 | — | — | 1 | 5.16 |
| CHEMBL265320 | — | — | 1 | 5.15 |
| CHEMBL70433 | — | — | 1 | 5.09 |
| CHEMBL307767 | NETROPSIN | — | 1 | 4.35 |
| CHEMBL11252 | STALLIMYCIN | 2.0 | 1 | 4.26 |
| CHEMBL72353 | — | — | 1 | - |
| CHEMBL72927 | — | — | 1 | - |
| CHEMBL312690 | — | — | 1 | - |
| CHEMBL266468 | — | — | 1 | - |
| CHEMBL386919 | — | — | 1 | - |
| CHEMBL74459 | — | — | 1 | - |
| CHEMBL74406 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 87.8 | nM | 7.06 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL72627 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL72828 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL311855 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL64874 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL73002 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL312306 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL265320 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL70433 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL307767 | NETROPSIN | IC50 | = | 44700.0 | nM | 4.35 |
| CHEMBL11252 | STALLIMYCIN | IC50 | = | 54700.0 | nM | 4.26 |
| CHEMBL72353 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL72927 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL312690 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL266468 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL386919 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL74459 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL74406 | — | IC50 | > | 10000.0 | nM | - |