Assay Detail
Functional
CHEMBL690540
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Compound was tested for inhibition of folinic acid transport in H35 Hepatoma cells.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | H35R0.3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.25 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308279 | — | — | 1 | 5.82 |
| CHEMBL307486 | — | — | 1 | 5.26 |
| CHEMBL65616 | — | — | 1 | 5.16 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308279 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL307486 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL65616 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 18000.0 | nM | 4.75 |