Assay Detail
Functional
CHEMBL690542
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Growth inhibition of H35 cell lines
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | H35 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Methotrexate analogues. 23. Synthesis, dihydrofolate reductase affinity, cytotoxicity, and in vivo antitumor activity of some putative degradation products of methotrexate-poly(L-lysine) conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.74 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.00 |
| CHEMBL171937 | — | — | 1 | 6.40 |
| CHEMBL344876 | — | — | 1 | 6.30 |
| CHEMBL3143620 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL171937 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL344876 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3143620 | — | IC50 | = | 560.0 | nM | 6.25 |