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Assay Detail

CHEMBL690663

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat isolated gastric (H(+)/K(+))-ATPase.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Stomach
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Potassium-transporting ATPase (CHEMBL2095199)
Type PROTEIN COMPLEX
Organism Rattus norvegicus

Publication

Reversible inhibitors of the gastric (H+/K+)-ATPase. 2. 1-Arylpyrrolo[3,2-c]quinolines: effect of the 4-substituent.
Leach CA, Brown TH, Ife RJ, Keeling DJ, Laing SM, Parsons ME, Price CA, Wiggall KJ.
J Med Chem (1992) 35 : 1845 -1852
PubMed 1316968 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.20 7.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL298695 1 7.19
CHEMBL52355 1 6.77
CHEMBL54511 1 6.75
CHEMBL54912 1 6.66
CHEMBL300848 1 6.66
CHEMBL301005 1 6.60
CHEMBL292179 1 6.55
CHEMBL55192 1 6.55
CHEMBL52811 1 6.54
CHEMBL52718 1 6.39
CHEMBL52527 1 6.36
CHEMBL51901 1 6.07
CHEMBL294877 1 6.01
CHEMBL54813 1 5.99
CHEMBL298396 1 5.96
CHEMBL54799 1 5.91
CHEMBL55106 1 5.89
CHEMBL416293 1 5.30
CHEMBL292912 1 5.30
CHEMBL299807 1 4.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL298695 IC50 = 64.0 nM 7.19
CHEMBL52355 IC50 = 170.0 nM 6.77
CHEMBL54511 IC50 = 180.0 nM 6.75
CHEMBL54912 IC50 = 220.0 nM 6.66
CHEMBL300848 IC50 = 220.0 nM 6.66
CHEMBL301005 IC50 = 250.0 nM 6.60
CHEMBL292179 IC50 = 280.0 nM 6.55
CHEMBL55192 IC50 = 280.0 nM 6.55
CHEMBL52811 IC50 = 290.0 nM 6.54
CHEMBL52718 IC50 = 410.0 nM 6.39
CHEMBL52527 IC50 = 440.0 nM 6.36
CHEMBL51901 IC50 = 850.0 nM 6.07
CHEMBL294877 IC50 = 980.0 nM 6.01
CHEMBL54813 IC50 = 1030.0 nM 5.99
CHEMBL298396 IC50 = 1100.0 nM 5.96
CHEMBL54799 IC50 = 1230.0 nM 5.91
CHEMBL55106 IC50 = 1290.0 nM 5.89
CHEMBL416293 IC50 = 4970.0 nM 5.30
CHEMBL292912 IC50 = 4970.0 nM 5.30
CHEMBL299807 IC50 = 33400.0 nM 4.48