Assay Detail
Binding
CHEMBL690673
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Inhibition of H+/K+ ATPase activity in buffered solution (pH 7.4)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]-benzothiazolidine derivatives as a potential gastric H+/K(+)-ATPase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.63 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1503 | OMEPRAZOLE | 4.0 | 1 | 5.42 |
| CHEMBL57148 | — | — | 1 | 4.62 |
| CHEMBL58681 | — | — | 1 | 4.48 |
| CHEMBL54932 | — | — | 1 | 4.01 |
| CHEMBL58203 | — | — | 1 | - |
| CHEMBL433094 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1503 | OMEPRAZOLE | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL57148 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL58681 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL54932 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL58203 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL433094 | — | IC50 | > | 100000.0 | nM | - |