Assay Detail
Functional
CHEMBL690684
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Tested for antiviral activity against Herpes simplex virus type-1 using plaque assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, antiproliferative, and antiviral activity of 4-amino-1-(beta-D-ribofuranosyl)pyrrolo[2,3-d]pyridazin-7(6H)-one and related derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.09 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2093055 | — | — | 1 | 5.70 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.46 |
| CHEMBL62099 | — | — | 1 | 5.40 |
| CHEMBL609505 | — | — | 1 | 5.35 |
| CHEMBL611857 | — | — | 1 | 5.17 |
| CHEMBL611541 | — | — | 1 | 4.52 |
| CHEMBL2092780 | — | — | 1 | 4.05 |
| CHEMBL3144065 | — | — | 1 | - |
| CHEMBL603718 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2093055 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL62099 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL609505 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL611857 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL611541 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2092780 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL3144065 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL603718 | — | IC50 | > | 100000.0 | nM | - |