Assay Detail
Functional
CHEMBL690689
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Tested for inhibition of the human umbilical vein endothelial cell (HUVEC) proliferation
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Investigation of novel fumagillin analogues as angiogenesis inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.36 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368349 | — | — | 1 | 9.28 |
| CHEMBL176975 | — | — | 1 | 9.19 |
| CHEMBL32838 | FUMAGILLIN | 2.0 | 1 | 9.09 |
| CHEMBL367938 | — | — | 1 | 9.05 |
| CHEMBL172123 | — | — | 1 | 8.52 |
| CHEMBL172883 | — | — | 1 | 7.06 |
| CHEMBL174250 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368349 | — | EC50 | = | 0.52 | nM | 9.28 |
| CHEMBL176975 | — | EC50 | = | 0.65 | nM | 9.19 |
| CHEMBL32838 | FUMAGILLIN | EC50 | = | 0.82 | nM | 9.09 |
| CHEMBL367938 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL172123 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL172883 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL174250 | — | EC50 | = | 450.0 | nM | 6.35 |