Assay Detail
Functional
CHEMBL690700
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of in vitro cell Human umbilical vein endothelial (HUVEC) cell proliferation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and related 2-urea derivatives are potent and selective inhibitors of the FGF receptor-1 tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.99 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135889 | — | — | 1 | 8.40 |
| CHEMBL134354 | — | — | 1 | 8.26 |
| CHEMBL135074 | — | — | 1 | 7.77 |
| CHEMBL339856 | — | — | 1 | 7.07 |
| CHEMBL422625 | — | — | 1 | 6.77 |
| CHEMBL299763 | — | — | 1 | 6.24 |
| CHEMBL133604 | — | — | 1 | 6.09 |
| CHEMBL134334 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135889 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL134354 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL135074 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL339856 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL422625 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL299763 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL133604 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL134334 | — | IC50 | = | 4900.0 | nM | 5.31 |