Assay Detail
Functional
CHEMBL690838
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Inhibition of the growth against human Colon Carcinoma (HT-29) cell line after 72 hr exposure
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of nonaromatic taxoids: effects of alkyl and alkenyl ester groups on cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.20 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339531 | — | — | 1 | 9.22 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.92 |
| CHEMBL95734 | — | — | 1 | 8.85 |
| CHEMBL318368 | — | — | 1 | 8.77 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.49 |
| CHEMBL318914 | — | — | 1 | 8.46 |
| CHEMBL321365 | — | — | 1 | 8.25 |
| CHEMBL95487 | — | — | 1 | 8.25 |
| CHEMBL319735 | — | — | 1 | 8.07 |
| CHEMBL93429 | — | — | 1 | 7.80 |
| CHEMBL318400 | — | — | 1 | 7.28 |
| CHEMBL98348 | — | — | 1 | 7.23 |
| CHEMBL317148 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339531 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL95734 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL318368 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL318914 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL321365 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL95487 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL319735 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL93429 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL318400 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL98348 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL317148 | — | IC50 | = | 89.0 | nM | 7.05 |