Assay Detail

CHEMBL690852

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

In Vitro Activity of Compound Against H157 non-small-cell lung tumor line (non-SCLC) cultures.

ChEMBL ↗

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Target

NCI-H157 (CHEMBL614783) ↗

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Primary target NCI-H157

CHEMBL614783

Anchored from Assay target.

Protein identity NCI-H157

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	NCI-H157
Confidence	1 — Organism
Curated By	Intermediate

Target

NCI-H157 (CHEMBL614783) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Terminally alkylated polyamine analogues as chemotherapeutic agents.

Casero RA, Woster PM.
J Med Chem (2001) 44 : 1 -26
PubMed 11141084 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.54	5.54

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL18794	BIS(ETHYL)SPERMINE	—	1	5.54

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL18794	BIS(ETHYL)SPERMINE	IC50	=	2900.0	nM	5.54