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Assay Detail

CHEMBL690911

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Ability to inhibit 50% growth of HeLa cells
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Expert

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and DNA-binding properties of polyamine analogues.
Edwards ML, Snyder RD, Stemerick DM.
J Med Chem (1991) 34 : 2414 -2420
PubMed 1875339 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 4.58 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL420586 1 6.00
CHEMBL79069 1 5.70
CHEMBL40258 1 5.30
CHEMBL78246 1 5.00
CHEMBL78198 1 5.00
CHEMBL81614 1 5.00
CHEMBL29142 1 4.82
CHEMBL79044 1 4.70
CHEMBL80796 1 4.70
CHEMBL82254 1 4.70
CHEMBL80480 1 4.52
CHEMBL28489 1 4.30
CHEMBL23194 SPERMINE 0.5 1 4.30
CHEMBL78409 1 4.22
CHEMBL82255 1 4.22
CHEMBL81145 1 4.12
CHEMBL81422 1 4.10
CHEMBL78612 1 4.05
CHEMBL29818 1 4.00
CHEMBL19612 SPERMIDINE 3.0 1 4.00
CHEMBL81149 1 4.00
CHEMBL28743 NORSPERMIDINE 1 4.00
CHEMBL27912 1 -
CHEMBL77442 1 -
CHEMBL81075 1 -
CHEMBL81822 1 -
CHEMBL284417 1 -
CHEMBL46257 PUTRESCINE 3.0 1 -
CHEMBL78613 1 -
CHEMBL79172 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL420586 IC50 = 1000.0 nM 6.00
CHEMBL79069 IC50 = 2000.0 nM 5.70
CHEMBL40258 IC50 = 5000.0 nM 5.30
CHEMBL78246 IC50 = 10000.0 nM 5.00
CHEMBL78198 IC50 = 10000.0 nM 5.00
CHEMBL81614 IC50 = 10000.0 nM 5.00
CHEMBL29142 IC50 = 15000.0 nM 4.82
CHEMBL79044 IC50 = 20000.0 nM 4.70
CHEMBL80796 IC50 = 20000.0 nM 4.70
CHEMBL82254 IC50 = 20000.0 nM 4.70
CHEMBL80480 IC50 = 30000.0 nM 4.52
CHEMBL28489 IC50 = 50000.0 nM 4.30
CHEMBL23194 SPERMINE IC50 = 50000.0 nM 4.30
CHEMBL78409 IC50 = 60000.0 nM 4.22
CHEMBL82255 IC50 = 60000.0 nM 4.22
CHEMBL81145 IC50 = 75000.0 nM 4.12
CHEMBL81422 IC50 = 80000.0 nM 4.10
CHEMBL78612 IC50 = 90000.0 nM 4.05
CHEMBL28743 NORSPERMIDINE IC50 = 100000.0 nM 4.00
CHEMBL81149 IC50 = 100000.0 nM 4.00
CHEMBL29818 IC50 = 100000.0 nM 4.00
CHEMBL19612 SPERMIDINE IC50 = 100000.0 nM 4.00
CHEMBL81759 IC50 > 500000.0 nM -
CHEMBL439761 IC50 > 500000.0 nM -
CHEMBL80874 IC50 = 200000.0 nM -
CHEMBL422415 IC50 = 125000.0 nM -
CHEMBL82549 IC50 = 125000.0 nM -
CHEMBL80850 IC50 = 400000.0 nM -
CHEMBL28866 IC50 = 350000.0 nM -
CHEMBL82252 IC50 > 500000.0 nM -
CHEMBL80313 IC50 > 500000.0 nM -
CHEMBL27909 IC50 = 200000.0 nM -
CHEMBL79172 IC50 > 500000.0 nM -
CHEMBL78613 IC50 = 160000.0 nM -
CHEMBL46257 PUTRESCINE IC50 = 8000000.0 nM -
CHEMBL284417 IC50 > 500000.0 nM -
CHEMBL81822 IC50 = 500000.0 nM -
CHEMBL81075 IC50 = 300000.0 nM -
CHEMBL77442 IC50 = 150000.0 nM -
CHEMBL27912 IC50 > 500000.0 nM -