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Assay Detail

CHEMBL691051

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of polymerization in wild type HIV-1 RT with poly rC/dG12-18 template primer and [3H]dGTP
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247)
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase.
Tillekeratne LM, Sherette A, Grossman P, Hupe L, Hupe D, Hudson RA.
Bioorg Med Chem Lett (2001) 11 : 2763 -2767
PubMed 11591519 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.99 6.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL297453 EPIGALOCATECHIN GALLATE 3.0 1 6.14
CHEMBL36327 EPICATECHIN GALLATE 1 6.12
CHEMBL328046 1 5.42
CHEMBL92138 1 4.97
CHEMBL96321 1 4.44
CHEMBL96112 1 4.43
CHEMBL93130 1 4.34
CHEMBL328142 1 4.02
CHEMBL93249 1 -
CHEMBL583912 (-)-EPICATECHIN 2.0 1 -
CHEMBL92678 1 -
CHEMBL92677 1 -
CHEMBL288114 GALLIC ACID 2.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL297453 EPIGALOCATECHIN GALLATE IC50 = 730.0 nM 6.14
CHEMBL36327 EPICATECHIN GALLATE IC50 = 760.0 nM 6.12
CHEMBL328046 IC50 = 3830.0 nM 5.42
CHEMBL92138 IC50 = 10740.0 nM 4.97
CHEMBL96321 IC50 = 36290.0 nM 4.44
CHEMBL96112 IC50 = 37240.0 nM 4.43
CHEMBL93130 IC50 = 45500.0 nM 4.34
CHEMBL328142 IC50 = 96300.0 nM 4.02
CHEMBL93249 IC50 > 100000.0 nM -
CHEMBL583912 (-)-EPICATECHIN IC50 > 100000.0 nM -
CHEMBL92678 IC50 > 100000.0 nM -
CHEMBL92677 IC50 > 100000.0 nM -
CHEMBL288114 GALLIC ACID IC50 > 100000.0 nM -