Assay Detail
Functional
CHEMBL691160
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against respiratory syncytial virus in HEp-2 human lung epithelial carcinoma cell line
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEp-2 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 56 | 7.48 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277331 | — | — | 1 | 8.40 |
| CHEMBL418539 | — | — | 1 | 8.40 |
| CHEMBL280443 | — | — | 1 | 8.40 |
| CHEMBL279576 | — | — | 1 | 8.40 |
| CHEMBL14480 | — | — | 1 | 8.30 |
| CHEMBL14710 | — | — | 1 | 8.30 |
| CHEMBL429613 | — | — | 1 | 8.30 |
| CHEMBL14564 | — | — | 1 | 8.30 |
| CHEMBL429040 | — | — | 1 | 8.22 |
| CHEMBL15109 | — | — | 1 | 8.15 |
| CHEMBL14777 | — | — | 1 | 8.10 |
| CHEMBL15042 | — | — | 1 | 8.05 |
| CHEMBL14821 | — | — | 1 | 8.00 |
| CHEMBL14980 | — | — | 1 | 7.96 |
| CHEMBL278731 | — | — | 1 | 7.96 |
| CHEMBL14804 | — | — | 1 | 7.92 |
| CHEMBL15145 | — | — | 1 | 7.89 |
| CHEMBL14852 | — | — | 1 | 7.85 |
| CHEMBL274242 | — | — | 1 | 7.82 |
| CHEMBL276796 | — | — | 1 | 7.80 |
| CHEMBL14583 | — | — | 1 | 7.75 |
| CHEMBL14567 | — | — | 1 | 7.75 |
| CHEMBL14684 | — | — | 1 | 7.68 |
| CHEMBL14481 | — | — | 1 | 7.68 |
| CHEMBL14456 | — | — | 1 | 7.60 |
| CHEMBL15040 | — | — | 1 | 7.60 |
| CHEMBL15066 | — | — | 1 | 7.57 |
| CHEMBL15133 | — | — | 1 | 7.55 |
| CHEMBL15009 | — | — | 1 | 7.55 |
| CHEMBL14954 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277331 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL279576 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL280443 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL418539 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL14480 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL14710 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL429613 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL14564 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL429040 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL15109 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL14777 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL15042 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL14821 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL278731 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL14980 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL14804 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL15145 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL14852 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL274242 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL276796 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL14583 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL14567 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL14684 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL14481 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL15040 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL14456 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL15066 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL15133 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL15009 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL14954 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL280276 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL14591 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL276790 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL14810 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL277534 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL417081 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL14486 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL15094 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL14858 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL279799 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL15082 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL14878 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL14785 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL417622 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL15281 | — | EC50 | = | 99.0 | nM | 7.00 |
| CHEMBL14907 | — | EC50 | = | 112.0 | nM | 6.95 |
| CHEMBL279798 | — | EC50 | = | 114.0 | nM | 6.94 |
| CHEMBL277987 | — | EC50 | = | 173.0 | nM | 6.76 |
| CHEMBL280519 | — | EC50 | = | 191.0 | nM | 6.72 |
| CHEMBL14603 | — | EC50 | = | 229.0 | nM | 6.64 |