Assay Detail
Functional
CHEMBL691288
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Compound was tested for biological activity against human colon carcinoma cell line HT-29/219
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
DNA threading agents: effect of sidechain bulk on DNA binding and cytotoxicity of 9-anilinoacridine-4-carboxamides
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.64 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57838 | — | — | 1 | 7.21 |
| CHEMBL37656 | — | — | 1 | 6.85 |
| CHEMBL299509 | — | — | 1 | 6.24 |
| CHEMBL52805 | — | — | 1 | 5.48 |
| CHEMBL53144 | — | — | 1 | 5.44 |
| CHEMBL431915 | — | — | 1 | 5.33 |
| CHEMBL299427 | — | — | 1 | 5.28 |
| CHEMBL416310 | — | — | 1 | 5.25 |
| CHEMBL301764 | — | — | 1 | 5.24 |
| CHEMBL415947 | — | — | 1 | 5.24 |
| CHEMBL55037 | — | — | 1 | 5.11 |
| CHEMBL299386 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57838 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL37656 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL299509 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL52805 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL53144 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL431915 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL299427 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL416310 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL301764 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL415947 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL55037 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL299386 | — | IC50 | = | 9800.0 | nM | 5.01 |