Assay Detail
Functional
CHEMBL691290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell proliferation of human colon HT-29X tumor xenograft in colony forming assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, cytotoxicity, and antitumor activity of copper(II) and iron(II) complexes of (4)N-azabicyclo[3.2.2]nonane thiosemicarbazones derived from acyl diazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.62 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68899 | — | — | 1 | 9.80 |
| CHEMBL71931 | N-[(1E)-1-(3-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | — | 1 | 9.07 |
| CHEMBL303030 | N-[(1E)-1-(5-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | — | 1 | 9.00 |
| CHEMBL307750 | N-[(1E)-1-(6-methylpyrimidin-4-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | — | 1 | 8.30 |
| CHEMBL68043 | — | — | 1 | 8.00 |
| CHEMBL307351 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68899 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL71931 | N-[(1E)-1-(3-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL303030 | N-[(1E)-1-(5-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL307750 | N-[(1E)-1-(6-methylpyrimidin-4-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL68043 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL307351 | — | IC50 | = | 28.0 | nM | 7.55 |