Assay Detail
Functional
CHEMBL691297
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Cytotoxicity against HTB-54 lung carcinoma cell line
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Calu-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and cytotoxic activity of N-(2-pyridylsulfenyl)urea derivatives. A new class of potential antineoplastic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.30 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.96 |
| CHEMBL75064 | — | — | 1 | 5.80 |
| CHEMBL309813 | — | — | 1 | 5.75 |
| CHEMBL77950 | — | — | 1 | 4.85 |
| CHEMBL77093 | — | — | 1 | 4.13 |
| CHEMBL430989 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL75064 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL309813 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL77950 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL77093 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL430989 | — | IC50 | > | 100000.0 | nM | - |