Assay Detail
Binding
CHEMBL691398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition HIV-1 IIIB protease.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and activity of conformationally-constrained macrocyclic peptide-based inhibitors of HIV protease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.76 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.70 |
| CHEMBL72386 | — | — | 1 | 9.05 |
| CHEMBL68313 | — | — | 1 | 9.00 |
| CHEMBL433309 | — | — | 1 | 8.82 |
| CHEMBL72474 | — | — | 1 | 8.52 |
| CHEMBL431387 | — | — | 1 | 8.47 |
| CHEMBL305466 | — | — | 1 | 8.26 |
| CHEMBL305463 | — | — | 1 | 8.22 |
| CHEMBL306727 | — | — | 1 | 8.14 |
| CHEMBL306897 | — | — | 1 | 8.10 |
| CHEMBL70787 | — | — | 1 | 8.00 |
| CHEMBL431754 | — | — | 1 | 7.89 |
| CHEMBL305063 | — | — | 1 | 7.60 |
| CHEMBL430984 | — | — | 1 | 7.06 |
| CHEMBL305289 | — | — | 1 | 6.40 |
| CHEMBL302486 | — | — | 1 | 6.35 |
| CHEMBL304369 | — | — | 1 | 6.05 |
| CHEMBL305290 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL72386 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL68313 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL433309 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL72474 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL431387 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL305466 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL305463 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL306727 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL306897 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL70787 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL431754 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL305063 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL430984 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL305289 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL302486 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL304369 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL305290 | — | IC50 | = | 90000.0 | nM | 4.05 |