Assay Detail
Binding
CHEMBL691399
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human immunodeficiency virus type 1 (HIV-1) protease
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel conformationally constrained HIV-1 protease inhibitors: rational design, enzyme inhibition, and X-ray structure of an enzyme-inhibtor complex
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.39 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273775 | — | — | 1 | 6.66 |
| CHEMBL69604 | — | — | 1 | 6.60 |
| CHEMBL68528 | — | — | 1 | 6.22 |
| CHEMBL306640 | — | — | 1 | 5.84 |
| CHEMBL419262 | — | — | 1 | 5.22 |
| CHEMBL69243 | — | — | 1 | 4.57 |
| CHEMBL69250 | — | — | 1 | 4.53 |
| CHEMBL304135 | — | — | 1 | 4.43 |
| CHEMBL69362 | — | — | 1 | 4.41 |
| CHEMBL304732 | — | — | 1 | - |
| CHEMBL69538 | — | — | 1 | - |
| CHEMBL304594 | — | — | 1 | - |
| CHEMBL305836 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273775 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL69604 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL68528 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL306640 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL419262 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL69243 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL69250 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL304135 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL69362 | — | IC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL304732 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL69538 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL304594 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL305836 | — | IC50 | > | 100000.0 | nM | - |