Assay Detail
Binding
CHEMBL691400
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV-1 Protease
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Cyclic sulfone-3-carboxamides as novel P2-ligands for Ro 31-8959 based HIV-1 protease inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.81 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355316 | — | — | 1 | 8.04 |
| CHEMBL436252 | — | — | 1 | 7.63 |
| CHEMBL354884 | — | — | 1 | 7.26 |
| CHEMBL273317 | — | — | 1 | 7.12 |
| CHEMBL170195 | — | — | 1 | 7.11 |
| CHEMBL352747 | — | — | 1 | 7.00 |
| CHEMBL275389 | — | — | 1 | 6.85 |
| CHEMBL354379 | — | — | 1 | 6.78 |
| CHEMBL354805 | — | — | 1 | 6.71 |
| CHEMBL354169 | — | — | 1 | 6.70 |
| CHEMBL354309 | — | — | 1 | 6.47 |
| CHEMBL355133 | — | — | 1 | 6.19 |
| CHEMBL18086 | — | — | 1 | 5.76 |
| CHEMBL18603 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355316 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL436252 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL354884 | — | IC50 | = | 54.7 | nM | 7.26 |
| CHEMBL273317 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL170195 | — | IC50 | = | 78.4 | nM | 7.11 |
| CHEMBL352747 | — | IC50 | = | 98.8 | nM | 7.00 |
| CHEMBL275389 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL354379 | — | IC50 | = | 167.4 | nM | 6.78 |
| CHEMBL354805 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL354169 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL354309 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL355133 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL18086 | — | IC50 | = | 1745.0 | nM | 5.76 |
| CHEMBL18603 | — | IC50 | = | 2068.0 | nM | 5.68 |