Assay Detail
Binding
CHEMBL691402
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Binding affinity for HIV -1 Protease
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: novel biaryl indazoles as P2/P2' substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 9.76 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL82422 | — | — | 1 | 10.52 |
| CHEMBL107817 | — | — | 1 | 10.24 |
| CHEMBL109377 | — | — | 1 | 10.05 |
| CHEMBL323043 | — | — | 1 | 9.89 |
| CHEMBL108498 | — | — | 1 | 9.74 |
| CHEMBL321669 | — | — | 1 | 9.62 |
| CHEMBL323449 | — | — | 1 | 9.60 |
| CHEMBL108932 | — | — | 1 | 9.59 |
| CHEMBL322991 | — | — | 1 | 9.52 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 9.43 |
| CHEMBL107648 | — | — | 1 | 9.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL82422 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL107817 | — | Ki | = | 0.058 | nM | 10.24 |
| CHEMBL109377 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL323043 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL108498 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL321669 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL323449 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL108932 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL322991 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL163 | RITONAVIR | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL107648 | — | Ki | = | 0.61 | nM | 9.21 |