Assay Detail
Binding
CHEMBL691404
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Compound was tested for the inhibition activity against HIV-1 protease
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Rational design of irreversible, pseudo-C2-symmetric hiv-1 protease inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.85 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55197 | — | — | 1 | 10.00 |
| CHEMBL52809 | — | — | 1 | 8.40 |
| CHEMBL300705 | — | — | 1 | 7.96 |
| CHEMBL53328 | — | — | 1 | 7.80 |
| CHEMBL293061 | — | — | 1 | 7.16 |
| CHEMBL295499 | — | — | 1 | 7.12 |
| CHEMBL54394 | — | — | 1 | 6.52 |
| CHEMBL33775 | — | — | 1 | - |
| CHEMBL43294 | — | — | 1 | - |
| CHEMBL48565 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55197 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL52809 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL300705 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL53328 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL293061 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL295499 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL54394 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL33775 | — | Ki | = | 11000000.0 | nM | - |
| CHEMBL43294 | — | Ki | < | 1.0 | nM | - |
| CHEMBL48565 | — | Ki | < | 1.0 | nM | - |