Assay Detail
Binding
CHEMBL691412
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Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.35 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20342 | — | — | 1 | 6.58 |
| CHEMBL20091 | — | — | 1 | 5.82 |
| CHEMBL20633 | — | — | 1 | 5.55 |
| CHEMBL20586 | — | — | 1 | 5.21 |
| CHEMBL20702 | — | — | 1 | 5.07 |
| CHEMBL20117 | — | — | 1 | 4.62 |
| CHEMBL20758 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20342 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL20091 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL20633 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL20586 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL20702 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL20117 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL20758 | — | IC50 | = | 25000.0 | nM | 4.60 |